Ontogeny and phagocytic function of baboon lung dendritic cells

Ontogeny and Phagocytic Function of Baboon Lung Dendritic Cells

Dendritic cells (DCs) are the most potent antigen-presenting cells, but the ontogeny and functions of lung DCs are not known during prenatal period. Here, we isolated lung DC population from fetal (125-175 days of gestation age) and adult baboons. The cells were stained with fluorochrome-conjugated-HLA-DP, DQ, DR, CD1a, CD11c, CD14, CD40, CD80, CD86, CD209, CMKLR1, ILT7-specific antibodies, and...

Ontogeny and Life Cycle of Dendritic Cells

D endritic cells (DC) are bone marrow-derived professional antigen-presenting cells (APC) which link innate and adaptive immune responses and which exhibit the exclusive ability of initiating primary immune responses by promoting the proliferation and polarisation of antigen-specific naïve T lymphocytes. This unique capacity derives from their high level of expression of MHC, co-stimulatory and...

Improved Function and Maturation of Dendritic Cells Stimulated by Recombinant pp65 Protein: In vitro Design

Phagocytic properties of lung alveolar wall cells.

For the purpose to define the mechanism of heavy metal intoxication by inhalation, morphologic observations were made on rat lungs after nasal instillation of iron colloid particles of positive and negative electric charges. Histochemical observation was also made on the liver and spleen of these animals. The instilled iron colloid particles reach the alveolar cavity easily, as can be seen in t...

Maturation State and Function of Monocyte Derived Dendritic Cells in Liver Transplant Recipients

Background: Dendritic cells (DCs) are potent antigen presenting cells for triggering of the immune reaction post transplantation. These cells are centrally involved in the initiation of T cell-dependent immune responses. Objective: To compare the level of DC maturation and function in liver transplant recipients with healthy controls. Methods: In this study, twelve peripheral blood samples we...